Available historical data indicate the last name Oseguera existed in Spain in the early 1400s and appeared in Mexico when Spanish people came to America in the late 1400s. Throughout the 1500s and 1600s this name went through spelling changes and appeared in the Caribbean and some Central America countries.

Oseguera, Oceguera, Osegueda, Ocegueda, Ozeguera, Ozeguerra are the most commonly spelling variations now found all over the world, mostly in the Western hemisphere.