Available historical data indicate the last name Oseguera existed in Spain in the early 1400s and appeared in Mexico when Spanish explorers came to America in the late 1400s. Throughout the 1500s and 1600s this name went through spelling changes and appeared in the Caribbean and some Central America countries.

Oseguera, Oceguera, Osegueda, Ocegueda, Ozeguera, Ozeguerra are the most commonly spelling variations now found all over the world, mostly in the Western hemisphere.

The Osegueda Family Tree created in ancestry.com contains more than 500 names mostly associated with descendants of Seferino Osegueda, the father of Francisco Lino Osegueda. There are other Osegueda lineage in Central America, mostly in El Salvador however, no documentation has been found to document the connection or relationship among them.